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Expression of the zinc-finger transcription factor Osterix (SP7) in invasive breast cancer and its prognostic significance

7 Apr 2025

Abstract excerpt

INTRODUCTION: Osterix, encoded by SP7, is a transcription factor crucial in osteoblast differentiation and bone formation. While initially characterised in bone development, emerging evidence suggests its involvement in cancer, particularly breast cancer metastasis to bone. METHODS: Osterix protein expression was evaluated in 1340 early-stage invasive breast tumours by immunohistochemistry. Cytoplasmic and...

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PMID: 40192943
DOI: 10.1007/s13402-025-01062-9

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