Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative genomic analyses of secreted protein acidic and rich in cysteine and its role in cancer prediction.

Molecular medicine reports - 1 Sept 2014

Wang Bo, Chen Kai, Xu Wenming, Chen Di, Tang Wei, Xia Tian-Song

Abstract excerpt

Secreted protein acidic and rich in cysteine (SPARC), also termed osteonectin or basement‑membrane‑40 (BM‑40), is a matrix‑associated protein that elicits changes in cell shape, inhibits cell‑cycle progression and affects the synthesis of extracellular matrix (ECM). The final mature SPARC protein has 286 amino acids with three distinct domains, including an NH2‑terminal acidic domain (NT), follistatin‑like domain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genome
Share to Amphibians
Share to Birds

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fishes

Share to Mammals

Share to Meta-Analysis as Topic

Share to Osteonectin

Share to Proteomics

Source

Identifiers

PMID: 24938427
DOI: 10.3892/mmr.2014.2339

Genes

SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative genomic analyses of secreted protein acidic and rich in cysteine and its role in cancer prediction.PMID 24938427Read ↗

Associations of tumor suppressor SPARCL1 with cancer progression and prognosisSemantic proximity Read ↗

A prototypic matricellular protein in the tumor microenvironment—Where there's SPARC, there's fireSemantic proximity Read ↗

Molecular mechanisms underlying the divergent roles of SPARC in human carcinogenesisSemantic proximity Read ↗

SPARCL1 Is a Novel Prognostic Biomarker and Correlates with Tumor Microenvironment in Colorectal CancerSemantic proximity Read ↗

The oncogenic functions of SPARCL1 in bladder cancerSemantic proximity Read ↗

Secreted Protein Acidic and Rich in Cysteine (SPARC) Enhances Cell Proliferation, Migration, and Epithelial Mesenchymal Transition, and SPARC Expression is Associated with Tumor Grade in Head and Neck Cancer.Semantic proximity Read ↗

The Expression of the Secreted Protein Acidic and Rich in Cysteine (SPARC) Is Associated with the Neoplastic Progression of Human MelanomaSemantic proximity Read ↗

Diagnosis and Prognostic Value of SPARC in Gastric Carcinoma: database mining for GCTASemantic proximity Read ↗

Cysteine-rich intestinal protein family: structural overview, functional diversity, and roles in human diseaseSemantic proximity Read ↗

The CAP Superfamily: Cysteine-Rich Secretory Proteins, Antigen 5, and Pathogenesis-Related 1 Proteins—Roles in Reproduction, Cancer, and Immune DefenseSemantic proximity Read ↗

ANALYSIS OF THE GENE EXPRESSION OF SPARC AND ITS PROGNOSTIC VALUE FOR BLADDER CANCERSemantic proximity Read ↗

Pan-cancer analysis of the oncogenic effect of SorCS1 in human tumors and its correlation with LRP2 proteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.