Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML

5 Oct 2009

Abstract excerpt

Deregulated cell survival programs are a classic hallmark of cancer. We have previously identified a serine residue (Ser585) in the betac subunit of the granulocyte-macrophage colony-stimulating factor receptor that selectively and independently promotes cell survival. We now show that Ser585 phosphorylation is constitutive in 20 (87%) of 23 acute myeloid leukemia (AML) patient samples, indicating that this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Dental Protein Studies
Share to Bone health and treatments
Share to Cancer Cells and Metastasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19805619
DOI: 10.1182/blood-2009-02-204818

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AMLPMID 19805619Read ↗

SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcomeSemantic proximity Read ↗

Dynamic single-cell network profiles in acute myelogenous leukemia are associated with patient response to standard induction therapy.Semantic proximity Read ↗

Osteopontin: role in cell signaling and cancer progressionSemantic proximity Read ↗

Osteopontin induces multiple changes in gene expression that reflect the six “hallmarks of cancer” in a model of breast cancer progressionSemantic proximity Read ↗

Role of osteopontin in the pathophysiology of cancerSemantic proximity Read ↗

Arginine methylation of the p30 C/EBPα oncoprotein regulates progenitor proliferation and myeloid differentiationSemantic proximity Read ↗

Role of osteopontin in cellular signaling and metastatic phenotype.Semantic proximity Read ↗

Human osteopontin: Potential clinical applications in cancer (Review)Semantic proximity Read ↗

Osteopontin Regulates Actin Cytoskeleton and Contributes to Cell Proliferation in Primary ErythroblastsSemantic proximity Read ↗

The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.