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Article

Super-enhancer-associated gene CAPG promotes AML progression

9 Jun 2023

Abstract excerpt

Acute myeloid leukemia is the most common acute leukemia in adults, the barrier of refractory and drug resistance has yet to be conquered in the clinical. Abnormal gene expression and epigenetic changes play an important role in pathogenesis and treatment. A super-enhancer is an epigenetic modifier that promotes pro-tumor genes and drug resistance by activating oncogene transcription. Multi-omics integrative...

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PMID: 37296281
DOI: 10.1038/s42003-023-04973-1

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