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Article

EVI1 induces myelodysplastic syndrome in mice

1 Sept 2004

Abstract excerpt

Myelodysplasia is a hematological disease in which genomic abnormalities accumulate in a hematopoietic stem cell leading to severe pancytopenia, multilineage differentiation impairment, and bone marrow (BM) apoptosis. Mortality in the disease results from pancytopenia or transformation to acute myeloid leukemia. There are frequent cytogenetic abnormalities, including deletions of chromosomes 5, 7, or both....

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PMID: 15343390
DOI: 10.1172/jci21716

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EVI1 induces myelodysplastic syndrome in micePMID 15343390Read ↗

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EVI1 expression predicts outcome in higher-risk myelodysplastic syndrome patients.Semantic proximity Read ↗

The MDS1–EVI1 Gene Complex as a Retrovirus Integration Site: Impact on Behavior of Hematopoietic Cells and Implications for Gene TherapySemantic proximity Read ↗

EVI1 Impairs Myelopoiesis by Deregulation of PU.1 FunctionSemantic proximity Read ↗

Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity.Semantic proximity Read ↗

VISTA mediates the progression of myelodysplastic syndromeSemantic proximity Read ↗

EVI1 and GATA2 misexpression induced by inv(3)(q21q26) contribute to megakaryocyte-lineage skewing and leukemogenesisSemantic proximity Read ↗

Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.Semantic proximity Read ↗

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