Article
Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity.
The Journal of experimental medicine - 21 Nov 2011
Kataoka Keisuke, Sato Tomohiko, Yoshimi Akihide, Goyama Susumu, Tsuruta Takako, Kobayashi Hiroshi, Shimabe Munetake, Arai Shunya, Nakagawa Masahiro, Imai Yoichi, Kumano Keiki, Kumagai Katsuyoshi, Kubota Naoto, Kadowaki Takashi, Kurokawa Mineo
Abstract excerpt
Ecotropic viral integration site 1 (Evi1), a transcription factor of the SET/PR domain protein family, is essential for the maintenance of hematopoietic stem cells (HSCs) in mice and is overexpressed in several myeloid malignancies. Here, we generate reporter mice in which an internal ribosome entry site (IRES)-GFP cassette is knocked-in to the Evi1 locus. Using these mice, we find that Evi1 is predominantly...
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