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Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1.

Cell reports - 17 Jan 2017

Nagaraj Ashwini S, Lahtela Jenni, Hemmes Annabrita, Pellinen Teijo, Blom Sami, Devlin Jennifer R, Salmenkivi Kaisa, Kallioniemi Olli, Mäyränpää Mikko I, Närhi Katja, Verschuren Emmy W

Abstract excerpt

Lung cancers exhibit pronounced functional heterogeneity, confounding precision medicine. We studied how the cell of origin contributes to phenotypic heterogeneity following conditional expression of KrasG12D and loss of Lkb1 (Kras;Lkb1). Using progenitor cell-type-restricted adenoviral Cre to target cells expressing surfactant protein C (SPC) or club cell antigen 10 (CC10), we show that Ad5-CC10-Cre-infected...

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PMID: 28099846
DOI: 10.1016/j.celrep.2016.12.059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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