Article
Genetic modifiers and subtypes in schizophrenia: investigations of age at onset, severity, sex and family history.
Schizophrenia research - 1 Apr 2014
Bergen Sarah E, O'Dushlaine Colm T, Lee Phil H, Fanous Ayman H, Ruderfer Douglas M, Ripke Stephan, Sullivan Patrick F, Smoller Jordan W, Purcell Shaun M, Corvin Aiden
Abstract excerpt
Schizophrenia is a genetically and clinically heterogeneous disorder. Genetic risk factors for the disorder may differ between the sexes or between multiply affected families compared to cases with no family history. Additionally, limited data support a genetic basis for variation in onset and severity, but specific loci have not been identified. We performed genome-wide association studies (GWAS) examining...
Topics
- Adolescent
- Adult
- Age of Onset
- Child
- Family
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Male
- Middle Aged
- Phenotype
- Risk Factors
- Schizophrenia