Article
Common genetic variants contribute to heritability of age at onset of schizophrenia.
Translational psychiatry - 13 Jun 2023
Sada-Fuente Ester, Aranda Selena, Papiol Sergi, Heilbronner Urs, Moltó María Dolores, Aguilar Eduardo J, González-Peñas Javier, Andreu-Bernabeu Álvaro, Arango Celso, Crespo-Facorro Benedicto, González-Pinto Ana, Fañanás Lourdes, Arias Barbara, Bobes Julio, Costas Javier, Martorell Lourdes, Schulze Thomas G, Kalman Janos L, Vilella Elisabet, Muntané Gerard
Abstract excerpt
Schizophrenia (SCZ) is a complex disorder that typically arises in late adolescence or early adulthood. Age at onset (AAO) of SCZ is associated with long-term outcomes of the disease. We explored the genetic architecture of AAO with a genome-wide association study (GWAS), heritability, polygenic risk score (PRS), and copy number variant (CNV) analyses in 4 740 subjects of European ancestry. Although no...
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