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Article

The impact of CNV burden on age at onset of schizophrenia.

Schizophrenia research - 1 May 2026

Muntané G, Valle A, Ramon-Cañellas P, Martorell L, Vilella E

Abstract excerpt

BACKGROUND: Schizophrenia (SCZ) is a severe neuropsychiatric disorder with a complex genetic architecture influenced by both common and rare variants. Disease age at onset (AAO) is a critical clinical feature, with earlier onset associated with greater severity and poorer functional outcomes. While copy number variants (CNVs) are well-established contributors to SCZ risk, their role in modulating AAO remains less...

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PMID: 41690160
DOI: 10.1016/j.schres.2026.02.006

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