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Article

Physical Origin of Thermostabilization by a Quadruple Mutation for the Adenosine A2a Receptor in the Active State.

The journal of physical chemistry. B - 26 Apr 2018

Kajiwara Yuta, Yasuda Satoshi, Hikiri Simon, Hayashi Tomohiko, Ikeguchi Mitsunori, Murata Takeshi, Kinoshita Masahiro

Abstract excerpt

The G protein-coupled receptors (GPCRs) form a large, physiologically important family of membrane proteins and are currently the most attractive targets for drug discovery. We investigate the physical origin of thermostabilization of the adenosine A2a receptor (A2aR) in the active state, which was experimentally achieved by another research group using the four point mutations: L48A, A54L, T65A, and Q89A. The...

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PMID: 29617137
DOI: 10.1021/acs.jpcb.8b00443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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