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Article

Glycogen synthase kinase 3β represses MYOGENIN function in alveolar rhabdomyosarcoma.

Cell death & disease - 27 Feb 2014

Dionyssiou M G, Ehyai S, Avrutin E, Connor M K, McDermott J C

Abstract excerpt

MYOGENIN is a member of the muscle regulatory factor family that orchestrates an obligatory step in myogenesis, the terminal differentiation of skeletal muscle cells. A paradoxical feature of alveolar rhabdomyosarcoma (ARMS), a prevalent soft tissue sarcoma in children arising from cells with a myogenic phenotype, is the inability of these cells to undergo terminal differentiation despite the expression of...

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Source

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Identifiers

PMID: 24577092
DOI: 10.1038/cddis.2014.58
PMCID: PMC3944270

Genes

FOXO1
PAX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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