Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PAX3-FOXO1 and FGFR4 in alveolar rhabdomyosarcoma.

Molecular carcinogenesis - 1 Oct 2012

Marshall Amy D, van der Ent Martijn A, Grosveld Gerard C

Abstract excerpt

We and others have identified FGFR4 as a direct transcriptional target of the alveolar rhabdomyosarcoma (ARMS) specific fusion protein, PAX3-FOXO1. We hypothesized fibroblast growth factor receptor 4 (FGFR4) may act as an effector of PAX3-FOXO1, contributing to PAX3-FOXO1 tumorigenic phenotypes. However, we demonstrate that enhanced expression of FGFR4 does not contribute to inhibited differentiation, enhanced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Cell Transformation, Neoplastic
Share to Mice, Mutant Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myoblasts

Share to Oncogene Proteins, Fusion

Share to Paired Box Transcription Factors

Share to Receptor, Fibroblast Growth Factor, Type 4

Share to Up-Regulation

Source

Identifiers

PMID: 21882254
DOI: 10.1002/mc.20848

Genes

FGFR4
FOXO1
PAX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PAX3-FOXO1 and FGFR4 in alveolar rhabdomyosarcoma.PMID 21882254Read ↗

FGFR4 Blockade Exerts Distinct Antitumorigenic Effects in Human Embryonal versus Alveolar RhabdomyosarcomaSemantic proximity Read ↗

PAX3-FOXO1 drives miR-486-5p and represses miR-221 contributing to pathogenesis of alveolar rhabdomyosarcomaSemantic proximity Read ↗

Therapeutic Approaches Targeting PAX3-FOXO1 and Its Regulatory and Transcriptional Pathways in RhabdomyosarcomaSemantic proximity Read ↗

PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitorsSemantic proximity Read ↗

Role of Myc family proteins in transcriptional regulation of growth and oncogenic transformation in fusion-positive rhabdomyosarcomaSemantic proximity Read ↗

Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models.Semantic proximity Read ↗

Genomic and Epigenetic Changes Drive Aberrant Skeletal Muscle Differentiation in RhabdomyosarcomaSemantic proximity Read ↗

A call to ARMS: targeting the<i>PAX3-FOXO1</i>gene in alveolar rhabdomyosarcomaSemantic proximity Read ↗

RUNX2 inhibition disrupts a PAX3::FOXO1-RUNX2 feed-forward loop and dismantles oncogenic gene programs in fusion-positive rhabdomyosarcomaSemantic proximity Read ↗

Fusions Involving PAX and FOX Genes in the Molecular Pathogenesis of Alveolar Rhabdomyosarcoma: Recent AdvancesSemantic proximity Read ↗

Identification of a PAX-FKHR Gene Expression Signature that Defines Molecular Classes and Determines the Prognosis of Alveolar RhabdomyosarcomasSemantic proximity Read ↗

PAX3–FOXO1 is essential for tumour initiation and maintenance but not recurrence in a human myoblast model of rhabdomyosarcomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.