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Article

Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.

The Journal of biological chemistry - 24 May 2002

Strano Sabrina, Fontemaggi Giulia, Costanzo Antonio, Rizzo Maria Giulia, Monti Olimpia, Baccarini Alessia, Del Sal Giannino, Levrero Massimo, Sacchi Ada, Oren Moshe, Blandino Giovanni

Abstract excerpt

The p53 tumor suppressor gene is the most frequent target for genetic alterations in human cancers, whereas the recently discovered homologues p73 and p63 are rarely mutated. We and others have previously reported that human tumor-derived p53 mutants can engage in a physical association with diff...

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Identifiers

PMID: 11893750
DOI: 10.1074/jbc.M201405200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11893750-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.PMID 11893750Read ↗

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