Article
The presence of KIR2DS5 confers protection against adult immune thrombocytopenia.
Tissue antigens - 1 Mar 2014
Seymour L A, Nourse J P, Crooks P, Wockner L, Bird R, Tran H, Gandhi M K
Abstract excerpt
Immune thrombocytopenia (ITP) is an autoimmune disorder of unknown aetiology, characterised by an isolated low platelet count in the absence of other identifiable causes. Genes influencing activation of the immune system have been identified as influencing predisposition. Killer cell immunoglobulin-like receptors (KIR) control T-cell and natural killer (NK) cell function via inhibitory and activating signalling...
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