Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variants in canonical Wnt signaling pathway associated with pediatric immune thrombocytopenia.

Blood advances - 12 Nov 2024

Kim Taylor Olmsted, Geris Jennifer M, Flanagan Jonathan M, Grace Rachael F, Lambert Michele P, O'Farrell Candelaria, Rose Melissa J, Shimano Kristin A, Niss Omar, Neunert Cindy, Nakano Taizo A, MacMath Derek, Dinu Bogdan, Kirk Susan E, Neufeld Ellis J, Despotovic Jenny M, Scheurer Michael E, Grimes Amanda B

Abstract excerpt

ABSTRACT: Through the use of genetic sequencing, molecular variants driving autoimmunity are increasingly identified in patients with chronic and refractory immune cytopenias. With the goal of discovering genetic variants that predispose to pediatric immune thrombocytopenia (ITP) or increase risk for chronic disease, we conducted a genome-wide association study in a large multi-institutional cohort of pediatric...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Genetic Variation

Share to Genome-Wide Association Study

Share to Infant

Share to Purpura, Thrombocytopenic, Idiopathic

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 39189922
DOI: 10.1182/bloodadvances.2024012776
PMCID: PMC11538615

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants in canonical Wnt signaling pathway associated with pediatric immune thrombocytopenia.PMID 39189922Read ↗

Association of rare variants in genes of immune regulation with pediatric autoimmune CNS diseases.Semantic proximity Read ↗

Deciphering the genetic basis of immune thrombocytopenia: current evidence for genetic predisposition in adult ITP.Semantic proximity Read ↗

The presence of KIR2DS5 confers protection against adult immune thrombocytopenia.Semantic proximity Read ↗

The KIR2DS2/DL2 genotype is associated with adult persistent/chronic and relapsed immune thrombocytopenia independently of FCGR3a-158 polymorphisms.Semantic proximity Read ↗

Genetic variants in toll-like receptor 4 are associated with lack of steroid-responsiveness in pediatric ITP patients.Semantic proximity Read ↗

STAT1 single nucleotide polymorphisms and susceptibility to immune thrombocytopenia.Semantic proximity Read ↗

Autoimmune cytopenia and Kabuki syndrome in paediatrics: Insights in 11 patients.Semantic proximity Read ↗

Differences in gene expression and cytokine levels between newly diagnosed and chronic pediatric ITPSemantic proximity Read ↗

Genetic studies in pediatric ITP: outlook, feasibility, and requirements.Semantic proximity Read ↗

Notch1-CD22-Dependent Immune Dysregulation in the SARS-CoV2-Associated Multisystem Inflammatory Syndrome in ChildrenSemantic proximity Read ↗

Stromal-derived factor-1 gene variations in pediatric patients with primary immune thrombocytopenia.Semantic proximity Read ↗

Gene mutations in the PI3K/Akt signaling pathway were related to immune thrombocytopenia pathogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.