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Article

Protective role of 5-azacytidine on myocardial infarction is associated with modulation of macrophage phenotype and inhibition of fibrosis.

Journal of cellular and molecular medicine - 1 Jun 2014

Kim Yong Sook, Kang Wan Seok, Kwon Jin Sook, Hong Moon Hwa, Jeong Hye-Yun, Jeong Hae Chang, Jeong Myung Ho, Ahn Youngkeun

Abstract excerpt

We examined whether a shift in macrophage phenotype could be therapeutic for myocardial infarction (MI). The mouse macrophage cell line RAW264.7 was stimulated with peptidoglycan (PGN), with or without 5-azacytidine (5AZ) treatment. MI was induced by ligation of the left anterior descending coronary artery in rats, and the rats were divided into two groups; a saline-injection group and a 5AZ-injection group...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24571348
DOI: 10.1111/jcmm.12248
PMCID: PMC4508142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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