Article
Topiramate modulates post-infarction inflammation primarily by targeting monocytes or macrophages.
Cardiovascular research - 1 Apr 2017
Wang Zhaohui, Huang Shiyuan, Sheng Yuling, Peng Xu, Liu Hui, Jin Nan, Cai Jun, Shu Yanwen, Li Ting, Li Ping, Fan Cheng, Hu Xiaofan, Zhang Wenyong, Long Rui, You Ya, Huang Caihong, Song Yi, Xiang Chunhua, Wang Jue, Yang Yong, Liu Kun
Abstract excerpt
AIMS: Monocytes/macrophages response plays a key role in post-infarction inflammation that contributes greatly to post-infarction ventricular remodelling and cardiac rupture. Therapeutic targeting of the GABAA receptor, which is enriched in monocytes/macrophages but not expressed in the myocardium, may be possible after myocardial infarction (MI). METHODS AND RESULTS: After MI was induced by ligation of the...
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