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Article

Adenosine kinase promotes post-infarction cardiac repair by epigenetically maintaining reparative macrophage phenotype.

Journal of molecular and cellular cardiology - 1 Jan 2023

Zhang Min, Wang Caiping, Wang Rongning, Xu Jiean, Wang Zhefeng, Yan Jianlong, Cai Yongfeng, Li Liangping, Huo Yuqing, Dong Shaohong

Abstract excerpt

Pro-inflammatory and reparative macrophages are crucial in clearing necrotic myocardium and promoting cardiac repair after myocardial infarction (MI), respectively. Extracellular adenosine has been demonstrated to modulate macrophage polarization through adenosine receptors. However, the role of intracellular adenosine in macrophage polarization has not been explored and adenosine kinase (ADK) is a major enzyme...

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Identifiers

PMID: 36473288
DOI: 10.1016/j.yjmcc.2022.11.007
PMCID: PMC10420407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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