The role of the ubiquitin-proteasome pathway in cardiovascular disease

Abstract excerpt

Whereas the mechanisms controlling cellular growth through protein synthesis have been investigated extensively in the cardiovascular system, especially in terms of cardiac cell hypertrophy and vascular smooth muscle cell proliferation, the processes by which endogenous proteins are degraded in these cells have received much less attention and have only begun to be revealed. The ubiquitin-proteasome system (UPS)...

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