Article
Haptoglobin and myeloperoxidase (- G463A) gene polymorphisms in Brazilian sickle cell patients with and without secondary iron overload.
Blood cells, molecules & diseases - 1 Jan 2000
Barbosa Lilian Carla, Miranda-Vilela Ana Luisa, Hiragi Cássia de Oliveira, Ribeiro Ieler Ferreira, Daldegan Margarete Barbosa, Grisolia Cesar Koppe, dos Santos-Neto Leopoldo Luiz
Abstract excerpt
We aimed to investigate the influence of haptoglobin (Hp) and myeloperoxidase (MPO - G463A; dbSNP rs2333227) gene polymorphisms on 78 sickle cell patients of a public hospital in the Federal District/Brazil with and without iron overload, to evaluate a possible association between these polymorphisms and clinical variability, response to treatment and prognosis. Data were obtained through laboratory tests,...
Topics
- Adult
- Aged
- Alleles
- Anemia, Sickle Cell
- Brazil
- Cross-Sectional Studies
- Erythrocyte Indices
- Female
- Gene Frequency
- Genotype
- Haptoglobins