Article

Risk Association of MTHFR Polymorphisms for Severity of the Disease in Children with Sickle Cell Disorder

2021-06-10

Abstract excerpt

<title>Abstract</title> <p>The MTHFR variants, C677T and A1298C have been reported to contribute towards higher severity in sickle cell disorder. Hence the study was conducted on children with sickle cell disease to find out the association of the genotypes of MTHFR and disease severity. A cross-sectional analytical study was conducted on 249 children aged 5–15 years, diagnosed with sickle cell disorder. Severity...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ab2371d7-931c-5dfe-a02e-e80dc5d1eda9
DOI: 10.21203/rs.3.rs-536063/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Risk Association of MTHFR Polymorphisms for Severity of the Disease in Children with Sickle Cell DisorderDOI 10.21203/rs.3.rs-536063/v1Read

Methylenetetrahydrofolate reductase polymorphisms as genetic markers to predict homocysteinemia and clinical severity in sickle cell disease.Semantic proximity Read

Assessment of MTR Rs1805087 SNP as Possible Modifier of Sickle Cell Disease Severity in a Nigerian Population.Semantic proximity Read

Relevance of Plasma Homocysteine and Methylenetetrahydrofolate Reductase 677TT Genotype in Sickle Cell Disease: A Systematic Review and Meta-Analysis.Semantic proximity Read

Sickle Cell Disease, a ReviewSemantic proximity Read

Sickle Cell DiseaseSemantic proximity Read

Genetic Variation and Sickle Cell Disease Severity: A Systematic Review and Meta-Analysis.Semantic proximity Read

Development of a Clinical Severity Score for Indian Sickle Cell Anaemia PatientsSemantic proximity Read

Minireview: Genetic basis of heterogeneity and severity in sickle cell diseaseSemantic proximity Read

MTHFR C677T Polymorphism, Plasma Homocysteine, and PDGF-AA Levels and Transcranial Doppler Velocity in Children With Sickle Cell Disease.Semantic proximity Read

Association of the methylenetetrahydrofolate reductase A1298C but not the C677T single nucleotide polymorphism with sickle cell disease in Bahrain.Semantic proximity Read

Sickle cell disease: A distinction of two most frequent genotypes (HbSS and HbSC).Semantic proximity Read

Three decades of innovation in the management of sickle cell disease: the road to understanding the sickle cell disease clinical phenotype.Semantic proximity Read