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Article

Impact of genetic polymorphisms in key enzymes of homocysteine metabolism on the pathophysiology of sickle cell anemia.

Free radical biology & medicine - 1 May 2017

da Silva Danilo Grünig Humberto, Belini Junior Edis, de Souza Torres Lidiane, Okumura Jessika Viviani, Marcel Barberino Willian, Garcia de Oliveira Renan, Urbinatti Teixeira Vanessa, Lopes de Castro Lobo Clarisse, Alves de Almeida Eduardo, Bonini-Domingos Claudia Regina

Abstract excerpt

This work aimed at studying a possible influence of methylenetetrahydrofolate reductase (MTHFR; c. 677C>T) and cystathionine β-synthase (CBS; 844ins68) polymorphisms on overall oxidative status of sickle cell anemia (SCA) patients and on routine markers, correlating them with hydroxycarbamide (HC) treatment. We evaluated 95 unrelated and diagnosed SCA patients. All patients received a prophylactic treatment with...

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Share to Anemia, Sickle Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Folic Acid

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

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Source

Identifiers

PMID: 28188925
DOI: 10.1016/j.freeradbiomed.2017.02.019

Genes

MTHFR
CBS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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