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Article

The effect of ABCG2 genotype on the population pharmacokinetics of sunitinib in patients with renal cell carcinoma.

Therapeutic drug monitoring - 1 Jun 2014

Mizuno Tomoyuki, Fukudo Masahide, Fukuda Tsuyoshi, Terada Tomohiro, Dong Min, Kamba Tomomi, Yamasaki Toshinari, Ogawa Osamu, Katsura Toshiya, Inui Ken-Ichi, Vinks Alexander A, Matsubara Kazuo

Abstract excerpt

BACKGROUND: Sunitinib, a multitargeted tyrosine kinase inhibitor, offers favorable therapeutic outcomes to patients with advanced renal cell carcinoma. However, to maximize the clinical benefits, an effective therapeutic management strategy with dose optimization is essential. The objectives of this analysis were to describe the pharmacokinetics (PK) of sunitinib by a population PK approach and to quantitatively...

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Source

Identifiers

PMID: 24825438
DOI: 10.1097/FTD.0000000000000025

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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