Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells

Abstract excerpt

Pro-inflammatory T cells co-express multiple chemokine receptors, but the distinct functions of individual receptors on these cells are largely unknown. Human Th17 cells uniformly express the chemokine receptor CCR6, and we discovered that the subgroup of CD4 + CCR6 + cells that co-express CCR2 possess a pathogenic Th17 signature, can produce inflammatory cytokines independent of TCR activation, and are unusuall...

Topics

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• Cell Adhesion Molecules Research
• Chemokine receptors and signaling
• Glycosylation and Glycoproteins Research
• Immune Cell Function and Interaction
• Immune Response and Inflammation
• Immunotherapy and Immune Responses
• Monoclonal and Polyclonal Antibodies Research
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

87af0a61-20ee-50da-a266-2ab40d5972d7

DOI

10.1101/2023.01.25.525561