Article
MAPT IVS1+124 C>G modifies risk of LRRK2 G2385R for Parkinson's disease in Chinese individuals.
Neurobiology of aging - 1 Jul 2014
Dan Xiaojuan, Wang Chaodong, Ma Jinghong, Feng Xiuli, Wang Tao, Zheng Zheng, Chan Piu
Abstract excerpt
Variants of the MAPT gene have been suggested to be associated with Parkinson's disease (PD) and to modify the risk for leucine-rich repeat kinase 2 (LRRK2) Parkinsonism. However, this has not been confirmed in Asians with ethnicity-specific variants of MAPT and LRRK2. In this study, Asian-specific LRRK2 p.G2385R variant and IVS1+124 C>G, a functional single-nucleotide polymorphism located in the MAPT promoter...
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