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Merotelic kinetochore attachment in oocyte meiosis II causes sister chromatids segregation errors in aged mice

21 Jul 2017

Abstract excerpt

Mammalian oocyte chromosomes undergo 2 meiotic divisions to generate haploid gametes. The frequency of chromosome segregation errors during meiosis I increase with age. However, little attention has been paid to the question of how aging affects sister chromatid segregation during oocyte meiosis II. More importantly, how aneuploid metaphase II (MII) oocytes from aged mice evade the spindle assembly checkpoint...

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PMID: 28590163
DOI: 10.1080/15384101.2017.1327488

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