Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Asymmetric segregation of damaged cellular components in spatially structured multicellular organisms.

PloS one - 1 Jan 2014

Strandkvist Charlotte, Juul Jeppe, Bendtsen Kristian Moss

Abstract excerpt

The asymmetric distribution of damaged cellular components has been observed in species ranging from fission yeast to humans. To study the potential advantages of damage segregation, we have developed a mathematical model describing ageing mammalian tissue, that is, a multicellular system of somatic cells that do not rejuvenate at cell division. To illustrate the applicability of the model, we specifically...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Apoptosis
Share to Cell Division

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to DNA, Mitochondrial

Share to Longevity

Share to Models, Statistical

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 24551071
DOI: 10.1371/journal.pone.0087917
PMCID: PMC3923766

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Asymmetric segregation of damaged cellular components in spatially structured multicellular organisms.PMID 24551071Read ↗

The protective role of symmetric stem cell division on the accumulation of heritable damage.Semantic proximity Read ↗

Unicellular life balances asymmetric allocation and repair of somatic damage representing the origin of r/K selectionSemantic proximity Read ↗

Symmetric vs. asymmetric stem cell divisions: an adaptation against cancer?Semantic proximity Read ↗

[Mechanisms of asymmetric cell division: from model organisms to tumorigenesis].Semantic proximity Read ↗

Constrained optimization of divisional load in hierarchically organized tissues during homeostasis.Semantic proximity Read ↗

Asymmetric Binomial Statistics Explains Organelle Partitioning Variance in Cancer Cell ProliferationSemantic proximity Read ↗

Optimal architecture of differentiation cascades with asymmetric and symmetric stem cell division.Semantic proximity Read ↗

Yeast mother cell-specific ageing, genetic (in)stability, and the somatic mutation theory of ageing.Semantic proximity Read ↗

Asymmetric organelle inheritance predicts human blood stem cell fateSemantic proximity Read ↗

Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations.Semantic proximity Read ↗

From zygote to a multicellular soma: body size affects optimal growth strategies under cancer riskSemantic proximity Read ↗

Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.