Article
Yeast mother cell-specific ageing, genetic (in)stability, and the somatic mutation theory of ageing.
Nucleic acids research - 1 Jan 2007
Laun Peter, Bruschi Carlo V, Dickinson J Richard, Rinnerthaler Mark, Heeren Gino, Schwimbersky Richard, Rid Raphaela, Breitenbach Michael
Abstract excerpt
Yeast mother cell-specific ageing is characterized by a limited capacity to produce daughter cells. The replicative lifespan is determined by the number of cell cycles a mother cell has undergone, not by calendar time, and in a population of cells its distribution follows the Gompertz law. Daughter cells reset their clock to zero and enjoy the full lifespan characteristic for the strain. This kind of replicative...
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