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CDH13 Is Associated with Cellular Viability After Exposure to Ionizing Radiation Using Genome-Wide Screening.

International journal of molecular sciences - 30 Jul 2026

Schmidt Hannah-Lena, Ohlei Olena, Herwest Sarah, Salewsky Bastian, Bertram Lars, Demuth Ilja

Abstract excerpt

It is well known that genetic variants contribute to cellular sensitivity to chemotherapeutic agents and ionizing radiation (IR). The aim of this study was to identify single nucleotide polymorphisms (SNPs) and genes associated with the spectrum of normal cellular sensitivity of lymphoblastoid cell lines (LCLs) towards ionizing radiation and mitomycin C (MMC). In the first step, we determined the viability of...

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Cadherins
Cell Line
Cell Survival
Genetic Risk Score
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Radiation, Ionizing

Source

Open in PubMed Open full text

Identifiers

PMID: 42589482
DOI: 10.3390/ijms27156826
PMCID: PMC13467385

Genes

CDH13
PLD5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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