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Article

A genome-wide association study using HapMap cell lines reveals modulators of cellular response to cyclophosphamide.

Future oncology (London, England) - 1 Jun 2025

Gbadamosi Mohammed O, Bhise Neha, Ghosh Taraswi Mitra, Molchan Elizabeth K, Streeks Kathleen, Puglise Jason, Ohaegbulam Alyssa, Makarem Mariana, Olabige Oluwaseyi, Yang Changlin, Ricks-Santi Luisel, Mitchell Duane A, Fridley Brooke L, Lamba Jatinder K

Abstract excerpt

AIMS: This study identifies single-nucleotide polymorphisms (SNPs) associated with cellular response to cyclophosphamide (CTX) using phosphoramide mustard (PM), its primary cytotoxic metabolite, and explores the downstream consequences for breast cancer (BC) patients. METHODS: We analyzed 1,978,545 SNPs from EBV-transformed lymphoblastic cell lines (LCLs) derived from 53 unrelated European individuals, in a...

Topics

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Antineoplastic Agents, Alkylating
Breast Neoplasms
Cell Line, Tumor
Cyclophosphamide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Drug Resistance, Neoplasm

Gene Expression Regulation, Neoplastic

Genome-Wide Association Study

Source

Open in PubMed Open full text

Identifiers

PMID: 40356407
DOI: 10.1080/14796694.2025.2501517
PMCID: PMC12150645

Genes

CTCF
KRT72

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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