Article
Genome-wide identification of chemosensitive single nucleotide polymorphism markers in gastric cancer.
Anticancer research - 1 Dec 2011
Ha Ye Jin, Yoon Sang Nam, Jeon Yeo Jin, Cho Dong Hyung, Roh Seon Ae, Kim Byung Sik, Kim Hee Jin, Kim Seon Young, Kim Yong Sung, Kim Jin Cheon
Abstract excerpt
A chemosensitive single nucleotide polymorphism (SNP) discovery schema is presented that utilizes (i) genome-wide SNP screening, with a human SNP array and an in vitro chemosensitivity assay, in 93 patients with gastric cancer (GC), and (ii) biological utility assessment using cell viability assays of transfected GC cells. Cytotoxicity analysis showed that most of the MKN1 and SNU638 clones transfected with the G...
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