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Article

Macrophages promote progression of spasmolytic polypeptide-expressing metaplasia after acute loss of parietal cells.

Gastroenterology - 1 Jun 2014

Petersen Christine P, Weis Victoria G, Nam Ki Taek, Sousa Josane F, Fingleton Barbara, Goldenring James R

Abstract excerpt

BACKGROUND & AIMS: Loss of parietal cells causes the development of spasmolytic polypeptide-expressing metaplasia (SPEM) through transdifferentiation of chief cells. In the presence of inflammation, SPEM can advance into a more proliferative metaplasia with increased expression of intestine-specific transcripts. We used L635 to induce acute SPEM with inflammation in mice and investigated the roles of inflammatory...

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Identifiers

PMID: 24534633
DOI: 10.1053/j.gastro.2014.02.007
PMCID: PMC4035414

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