Article
Why is ALS so Difficult to Treat?
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques - 1 Mar 2014
Turnbull John
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is proving intractable. Difficulties in pre-clinical studies contribute in small measure to this futility, but the chief reason for failure is an inadequate understanding of disease pathogenesis. Many acquired and inherited processes have been advanced as potential causes of ALS but, while they may predispose to disease, it seems increasingly likely that none leads directly to...
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