Article
Amyotrophic lateral sclerosis is a multifactorial disease.
Muscle & nerve - 1 Jul 1995
Eisen A
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is probably biphasic. An initial trigger(s) is followed by a terminal cascade coinciding with the onset of neurological deficits. The terminal cascade involves interactive multifactorial pathogenic mechanisms. Aging must play a crucial role leading to multiple...
Topics
- Amyotrophic Lateral Sclerosis
- Animals
- Chromosome Mapping
- Chromosomes, Human, Pair 21
- Glutamic Acid
- Humans
- Mutation
- Nerve Growth Factors
- Neurofilament Proteins
- Neurotoxins
- Receptors, N-Methyl-D-Aspartate
- Second Messenger Systems
- Signal Transduction
- Species Specificity
- Superoxide Dismutase