Article

A(a)LS: Ammonia-induced amyotrophic lateral sclerosis

2015-03-27

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a dreadful, devastating and incurable motor neuron disease. Aetiologically, it is a multigenic, multifactorial and multiorgan disease. Despite intense research, ALS pathology remains unexplained. After the literature review, this paper posits a new integrative explanation. This framework proposes that ammonia neurotoxicity is a main player in ALS pathogenesis. According to th...

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Literature Corpus work: 5306f2a3-8ef4-5d1e-a286-322843e5e784
DOI: 10.7287/peerj.preprints.935v1

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