Article

A(a)LS: Ammonia-induced amyotrophic lateral sclerosis

2015-05-14

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a dreadful, devastating and incurable motor neuron disease. Aetiologically, it is a multigenic, multifactorial and multiorgan disease. Despite intense research, ALS pathology remains unexplained. Following extensive literature review, this paper posits a new integrative explanation. This framework proposes that ammonia neurotoxicity is a main player in ALS pathogenesis. Accor...

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Literature Corpus work: 9618e20b-6598-50a6-9b56-2e2d02483788
DOI: 10.12688/f1000research.6364.1

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