Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Amyotrophic lateral sclerosis: Problems and prospects.

Annals of neurology - 1 Sept 2013

Sreedharan Jemeen, Brown Robert H

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a lethal degenerative disorder of motoneurons, which may occur concurrently with frontotemporal dementia. Genetic analyses of the ∼10% of ALS cases that are dominantly inherited provide insight into ALS pathobiology. Two broad themes are evident. One, prompted by investigations of the SOD1 gene, is that conformational instability of proteins triggers downstream neurotoxic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to FUS gene
Share to Genetic Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Therapy

Share to Motor Neurons

Share to Mutation

Share to RNA-Binding Protein FUS

Share to Superoxide Dismutase

Source

Identifiers

PMID: 24038380
DOI: 10.1002/ana.24012

Genes

FUS
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Amyotrophic lateral sclerosis: Problems and prospects.PMID 24038380Read ↗

Deciphering amyotrophic lateral sclerosis: what phenotype, neuropathology and genetics are telling us about pathogenesis.Semantic proximity Read ↗

Amyotrophic Lateral Sclerosis: New Insights into Underlying Molecular Mechanisms and Opportunities for Therapeutic InterventionSemantic proximity Read ↗

Advances and challenges in understanding the multifaceted pathogenesis of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Emerging mechanisms of molecular pathology in ALSSemantic proximity Read ↗

Genetics of amyotrophic lateral sclerosis: an updateSemantic proximity Read ↗

Amyotrophic lateral sclerosis: the complex path to precision medicineSemantic proximity Read ↗

State of the art and the dark side of amyotrophic lateral sclerosisSemantic proximity Read ↗

Amyotrophic lateral sclerosis: pathogenesis.Semantic proximity Read ↗

Current hypotheses for the underlying biology of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Amyotrophic lateral sclerosis: from current developments in the laboratory to clinical implications.Semantic proximity Read ↗

The changing scene of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Pathogenesis of amyotrophic lateral sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.