Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment.

Neurobiology of aging - 1 Jun 2014

Ali-Rahmani Fatima, Grigson Patricia S, Lee Sang, Neely Elizabeth, Connor James R, Schengrund Cara-Lynne

Abstract excerpt

The H63D variant of the hemochromatosis (HFE) gene, when expressed in carriers of the apolipoprotein E4 allele, is implicated as a risk factor for earlier onset of Alzheimer's disease (AD). We tested the hypothesis that like expression of apolipoprotein E4, expression of H63D-HFE disrupts cholesterol metabolism contributing to an increase in neurodegeneration and memory deficits. Analysis of SH-SY5Y human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspase 3
Share to Hemochromatosis
Share to Hemochromatosis Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Memory

Share to Memory Disorders

Share to Neurodegenerative Diseases

Share to Recognition, Psychology

Share to Steroid Hydroxylases

Source

Identifiers

PMID: 24439478
DOI: 10.1016/j.neurobiolaging.2013.12.014

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment.PMID 24439478Read ↗

A hemochromatosis allele that protects against Alzheimer's disease injury: A role for H-ferritin.Semantic proximity Read ↗

HFE mutations and Alzheimer's diseaseSemantic proximity Read ↗

HFE gene variants, iron, and lipids: a novel connection in Alzheimerâ€™s diseaseSemantic proximity Read ↗

Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues.Semantic proximity Read ↗

Interaction of the H63D mutation in the hemochromatosis gene with the apolipoprotein E epsilon 4 allele modulates age at onset of Alzheimer's disease.Semantic proximity Read ↗

Evaluation of HFE (hemochromatosis) mutations as genetic modifiers in sporadic AD and MCI.Semantic proximity Read ↗

Consequences of expressing mutants of the hemochromatosis gene (HFE) into a human neuronal cell line lacking endogenous HFE.Semantic proximity Read ↗

Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer's disease and correlation with APOE.Semantic proximity Read ↗

The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice.Semantic proximity Read ↗

Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease.Semantic proximity Read ↗

Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice.Semantic proximity Read ↗

H63D HFE genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.