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Article

Effect of HFE variants on sphingolipid expression by SH-SY5Y human neuroblastoma cells.

Neurochemical research - 1 Sept 2011

Ali-Rahmani F, Hengst J A, Connor J R, Schengrund C-L

Abstract excerpt

C282Y and H63D are two common variants of the hemochromatosis protein HFE. SH-SY5Y human neuroblastoma cells stably transfected to express either wild type HFE (WT-HFE), or the C282Y or H63D allele were analyzed for effect of expression of the mutant proteins on transcription of 14 enzymes involv...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21243428
DOI: 10.1007/s11064-011-0403-8

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21243428-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Effect of HFE variants on sphingolipid expression by SH-SY5Y human neuroblastoma cells.PMID 21243428Read ↗

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H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment.Semantic proximity Read ↗

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Hereditary hemochromatosis: effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells.Semantic proximity Read ↗

HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions.Semantic proximity Read ↗

The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin.Semantic proximity Read ↗

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