Article
Polymorphisms in the mitochondrial ribosome recycling factor EF-G2mt/MEF2 compromise cell respiratory function and increase atorvastatin toxicity.
PLoS genetics - 1 Jan 2012
Callegari Sylvie, Gregory Philip A, Sykes Matthew J, Bellon Jennifer, Andrews Stuart, McKinnon Ross A, de Barros Lopes Miguel A
Abstract excerpt
Mitochondrial translation, essential for synthesis of the electron transport chain complexes in the mitochondria, is governed by nuclear encoded genes. Polymorphisms within these genes are increasingly being implicated in disease and may also trigger adverse drug reactions. Statins, a class of HMG-CoA reductase inhibitors used to treat hypercholesterolemia, are among the most widely prescribed drugs in the world....
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