Article
A non-canonical initiation site is required for efficient translation of the dendritically localized Shank1 mRNA.
PloS one - 1 Jan 2014
Studtmann Katrin, Olschläger-Schütt Janin, Buck Friedrich, Richter Dietmar, Sala Carlo, Bockmann Jürgen, Kindler Stefan, Kreienkamp Hans-Jürgen
Abstract excerpt
Local protein synthesis in dendrites enables neurons to selectively change the protein complement of individual postsynaptic sites. Though it is generally assumed that this mechanism requires tight translational control of dendritically transported mRNAs, it is unclear how translation of dendritic mRNAs is regulated. We have analyzed here translational control elements of the dendritically localized mRNA coding...
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