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Article

The nuclear argonaute NRDE-3 contributes to transitive RNAi in Caenorhabditis elegans.

Genetics - 1 May 2013

Zhuang Jimmy J, Banse Stephen A, Hunter Craig P

Abstract excerpt

The Caenorhabditis elegans nuclear RNA interference defective (Nrde) mutants were identified by their inability to silence polycistronic transcripts in enhanced RNAi (Eri) mutant backgrounds. Here, we report additional nrde-3-dependent RNAi phenomena that extend the mechanisms, roles, and functions of nuclear RNAi. We show that nrde-3 mutants are broadly RNAi deficient and that overexpressing NRDE-3 enhances...

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Identifiers

PMID: 23457236
DOI: 10.1534/genetics.113.149765
PMCID: PMC3632460

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Source receipt: pubmed, retrieved 7 Sept 2026.

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