Article
Delineating immune-mediated mechanisms underlying hair follicle destruction in the mouse mutant defolliculated.
The Journal of investigative dermatology - 1 Mar 2011
Ruge Fiona, Glavini Aikaterini, Gallimore Awen M, Richards Hannah E, Thomas Christopher P, O'Donnell Valerie B, Philpott Michael P, Porter Rebecca M
Abstract excerpt
Defolliculated (Gsdma3(Dfl)/+) mice have a hair loss phenotype that involves an aberrant hair cycle, altered sebaceous gland differentiation with reduced sebum production, chronic inflammation, and ultimately the loss of the hair follicle. Hair loss in these mice is similar to that seen in primary cicatricial, or scarring alopecias in which immune targeting of hair follicle stem cells has been proposed as a key...
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