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Article

Role for ELOVL3 and Fatty Acid Chain Length in Development of Hair and Skin Function

1 Feb 2004

Abstract excerpt

Very little is known about the in vivo regulation of mammalian fatty acid chain elongation enzymes as well as the role of specific fatty acid chain length in cellular responses and developmental processes. Here, we report that the Elovl3 gene product, which belongs to a highly conserved family of microsomal enzymes involved in the formation of very long chain fatty acids, revealed a distinct expression in the...

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PMID: 14581464
DOI: 10.1074/jbc.m310529200

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Role for ELOVL3 and Fatty Acid Chain Length in Development of Hair and Skin FunctionPMID 14581464Read ↗

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Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival.Semantic proximity Read ↗

Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death.Semantic proximity Read ↗

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Physiological effects of inactivation and the roles of Elovl3/ELOVL3 in maintaining ocular homeostasis.Semantic proximity Read ↗

Retinal pathology and skin barrier defect in mice carrying a Stargardt disease-3 mutation in elongase of very long chain fatty acids-4.Semantic proximity Read ↗

In vivo effect of mutant ELOVL4 on the expression and function of wild-type ELOVL4.Semantic proximity Read ↗

Loss of Mpzl3 function causes various skin abnormalities and greatly reduced adipose depots.Semantic proximity Read ↗

Different Mutations in ELOVL4 Affect Very Long Chain Fatty Acid Biosynthesis to Cause Variable Neurological Disorders in Humans.Semantic proximity Read ↗

The role of fatty acid elongation in epidermal structure and functionSemantic proximity Read ↗

Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development.Semantic proximity Read ↗

Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency.Semantic proximity Read ↗

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