Article
A new Gsdma3 mutation affecting anagen phase of first hair cycle.
Biochemical and biophysical research communications - 10 Aug 2007
Tanaka Shigekazu, Tamura Masaru, Aoki Aya, Fujii Tomoaki, Komiyama Hiromitsu, Sagai Tomoko, Shiroishi Toshihiko
Abstract excerpt
Recombination-induced mutation 3 (Rim3) is a spontaneous mouse mutation that exhibits dominant phenotype of hyperkeratosis and hair loss. Fine linkage analysis of Rim3 and sequencing revealed a novel single point mutation, G1124A leading to Ala348Thr, in Gsdma3 in chromosome 11. Transgenesis with BAC DNA harboring the Rim3-type Gsdma3 recaptured the Rim3 phenotype, providing direct evidence that Gsdma3 is the...
Topics
- Animals
- Hair Follicle
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Transgenic
- Mitosis
- Mutation
- Neoplasm Proteins