Article
Differential effects of fingolimod on B-cell populations in multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Sept 2014
Nakamura Masakazu, Matsuoka Takako, Chihara Norio, Miyake Sachiko, Sato Wakiro, Araki Manabu, Okamoto Tomoko, Lin Youwei, Ogawa Masafumi, Murata Miho, Aranami Toshimasa, Yamamura Takashi
Abstract excerpt
BACKGROUND: Fingolimod is an oral drug approved for multiple sclerosis (MS) with an ability to trap central memory T cells in secondary lymphoid tissues; however, its variable effectiveness in individual patients indicates the need to evaluate its effects on other lymphoid cells. OBJECTIVE: To clarify the effects of fingolimod on B-cell populations in patients with MS. METHODS: We analysed blood samples from 9...
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