Anti-CD20 therapy depletes activated myelin-specific CD8 + T cells in multiple sclerosis

Abstract excerpt

Significance Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. CD8 + T cells have been strongly implicated in MS pathogenesis, but it is unclear whether myelin is a CD8 + T cell autoantigenic target in MS. This study demonstrated that while myelin-specific CD8 + T cells are present at similar frequencies in untreated MS patients and healthy subjects, the proportion of...

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