Article
Effect of growth rate and selection pressure on rates of transfer of an antibiotic resistance plasmid between E. coli strains.
Plasmid - 1 Mar 2014
Schuurmans Jasper M, van Hijum Sacha A F T, Piet Jurgen R, Händel Nadine, Smelt Jan, Brul Stanley, ter Kuile Benno H
Abstract excerpt
Antibiotic resistance increases costs for health care and causes therapy failure. An important mechanism for spreading resistance is transfer of plasmids containing resistance genes and subsequent selection. Yet the factors that influence the rate of transfer are poorly known. Rates of plasmid transfer were measured in co-cultures in chemostats of a donor and a acceptor strain under various selective pressures....
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