Compensatory mutations improve general permissiveness to antibiotic resistance plasmids.

doi:10.1038/s41559-017-0243-2

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Compensatory mutations improve general permissiveness to antibiotic resistance plasmids.

Nature ecology & evolution - 1 Sept 2017

Loftie-Eaton Wesley, Bashford Kelsie, Quinn Hannah, Dong Kieran, Millstein Jack, Hunter Samuel, Thomason Maureen K, Merrikh Houra, Ponciano Jose M, Top Eva M

Abstract excerpt

Horizontal gene transfer mediated by broad-host-range plasmids is an important mechanism of antibiotic resistance spread. While not all bacteria maintain plasmids equally well, plasmid persistence can improve over time, yet no general evolutionary mechanisms have emerged. Our goal was to identify these mechanisms and to assess if adaptation to one plasmid affects the permissiveness to others. We experimentally...

Topics

Bacterial Proteins
DNA Helicases
DNA-Directed RNA Polymerases
Drug Resistance, Microbial
Gene Transfer, Horizontal
Mutation
Plasmids
Pseudomonas

Source

Open in PubMed Open full text

Identifiers

PMID: 29046540
DOI: 10.1038/s41559-017-0243-2
PMCID: PMC5649373

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics